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    Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid
    Breakthroughs

    Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid

    PLOS Pathogens: Here we show that hypochlorous acid, a disinfectant that is produced naturally by certain cells within the body, has strong anti-pr...

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    Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen
    NIH

    Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

    Fibrinogen was oxidized by adding HOCl at physiologically relevant concentrations between 0–150 μmol HOCl/g fibrinogen (or ∼0–300 μM based on 2 mg/...

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    Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13
    Breakthroughs

    Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13

    We show in this study that neutrophil-derived oxidants are capable of readily oxidizing the methionine residue at the cleavage site for the VWF-pro...

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    Hypochlorous Acid as a Potential Wound Care Agent
    Antiseptic

    Hypochlorous Acid as a Potential Wound Care Agent

    HOCl is known to be the major strong oxidant produced by neutrophils, and is a potent microbicidal agent within these cells. Experimentally, it has...

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    Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella enteritidis, and Listeria monocytogenes
    Disinfection

    Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella enteritidis, and Listeria monocytogenes

    American Society for MicrobiologySeptember, 1999AbstractThe efficacy of electrolyzed oxidizing water for inactivating Escherichia coli O157:H7, Sal...

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    The Inhibition of Bacterial Growth by Hypochlorous Acid. Possible Role in the Bactericidal Activity of Phagocytes
    Infection Control

    The Inhibition of Bacterial Growth by Hypochlorous Acid. Possible Role in the Bactericidal Activity of Phagocytes

    These effects were apparent within 5 min of HOCl exposure, and were not reversed by extensive washings. DNA synthesis (incorporation of [3H]-thymid...

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    1915 Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment
    Antiseptic

    1915 Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment

    In our observations on the hypochlorites we found that hypochlorous acid is a more potent germicide than its salts, and we have accordingly-devised...

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