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What is HOCL?

Hypochlorous Acid

Hypochlorous Acid (HOCl) is a natural part of our internal defense system, produced by white blood cells through a process called phagocytosis. It has been a component of our natural defense system for millions of years. HOCl is the front line of our defense system and serves the dual purpose of fighting all types of germs that try to invade us and triggering a series of biochemical chain reactions to stimulate rapid healing and restore normal structure and function.

How Does Hypochlorous Acid Work?

When produced outside the body, HOCl is an electrolyzed, antimicrobial, biocide solution that inactivates pathogens such as bacteria, viruses, spores, and fungi.

  • Works to fight infection, reduce inflammation, and enhance healing
  • Part of the healthy response to control injury and recovery
  • Consistently shows no adverse effects
  • Soothing and fast-acting results
  • Will not irritate or aggravate tissue damage at wound sites
  • Steady control over the healing process that quickly becomes evident
  • No stinging sensation, unlike many other topically applied solutions
  • Non-hazardous for use on humans and animals

Real Science in the human body

Harmful pathogens, such as bacteria, spores and viruses, can be found all around us — in the air, on food, plants, animals, and on inanimate surfaces. The human body uses innate, non-specific mechanisms as the first line of defense against pathogens, infection and injury. 

The skin itself, and mucous secretions at epithelial membranes, are both important elements of the innate resistance response. But when these are breached, HOCl is immediately generated by the body in response as the key chemical component of innate immunity. A cascade of benefits comes about with this HOCl production. 
The mechanism of HOCl production from salt in the body involves intracellular enzymes, but outside the body the process can be mimicked by using controlled application of electrical energy instead — an electrochemical activation (ECA) process.

History of Hypochlorous Acid

As an antimicrobial, antiviral and antifungal that is non-hazardous for all mucosal contact, HOCl hurries healing, works to mitigate scarring, to clear a myriad of skin issues and conditions, can be misted to permeate small crevices for effective odor control and sanitation, and a review of HOCl attributes will show the following citations:

  • Reduces skin aging (anti-wrinkle effect) ¹ 
  • Makes blood clot in wounds ² 
  • Causes fibrinogen oxidation, firmer clots and longer clot lysis period ³ 
  • Stimulates immunity to germs  
  • Produces powerful local stimulants of wound healing/germ killing
  • Makes new skin cells grow over wounds and reorganizes scar fibers  ​
  • Leads to long lasting local effects in the body

    While the 100 year history of Hypochlorous Acid has provided indisputable evidence of its efficacy in healing and use in disinfection, and over 500 peer-reviewed, published papers universally document significant beneficial results, the widespread use of HOCl has remained fairly stagnant, and the primary limiting factor to broad adoption of this important technology, historically, has been due to its lack of stability.

HISTORY OF HYPOCHLOROUS

Hypochlorous Acid (HOCl)

Publications

Inhalation of Microaerosolized Hypochlorous Acid (HOCl): Biochemical, Antimicrobial, and Pathological Assessment
Immune Activation

Inhalation of Microaerosolized Hypochlorous Acid (HOCl): Biochemical, Antimicrobial, and Pathological Assessment

Inhalation of HOCl-containing aerosols was recently shown to be an effective therapeutic intervention in the treatment of COVID-19 virusinfected patients, halting the progression of symptoms and sp...

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Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid
Breakthroughs

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid

PLOS Pathogens: Here we show that hypochlorous acid, a disinfectant that is produced naturally by certain cells within the body, has strong anti-prion and anti-amyloid activity. We find that a non-...

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Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency
Antiseptic

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency

The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isol...

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The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is "Tragically Inadequate"
Antiseptic

The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is "Tragically Inadequate"

Neutralize toxins that eat away flesh by irrigating the wounds of necrotizing fasciitis patients with a substance called hypochlorous acid (HOCl), a natural chemical produced by white blood cells a...

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Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice
Inflammation

Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice

Exposure of human keratinοcytes to 0.005% HOCl for 1 hour prior to TNF-α stimulation eliminated the induction of both genes.

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Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen
NIH

Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Fibrinogen was oxidized by adding HOCl at physiologically relevant concentrations between 0–150 μmol HOCl/g fibrinogen (or ∼0–300 μM based on 2 mg/mL fibrinogen concentration) (22). Circular dichro...

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