HOCl Publications

Inhalation of Microaerosolized Hypochlorous Acid (HOCl): Biochemical, Antimicrobial, and Pathological Assessment

Inhalation of HOCl-containing aerosols was recently shown to be an effective therapeutic intervention in the treatment of COVID-19 virusinfected patients, halting the progression of symptoms and sp...

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid

PLOS Pathogens: Here we show that hypochlorous acid, a disinfectant that is produced naturally by certain cells within the body, has strong anti-prion and anti-amyloid activity. We find that a non-...

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency

The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isol...

The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is "Tragically Inadequate"

Neutralize toxins that eat away flesh by irrigating the wounds of necrotizing fasciitis patients with a substance called hypochlorous acid (HOCl), a natural chemical produced by white blood cells a...

Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice

Exposure of human keratinοcytes to 0.005% HOCl for 1 hour prior to TNF-α stimulation eliminated the induction of both genes.

Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Fibrinogen was oxidized by adding HOCl at physiologically relevant concentrations between 0–150 μmol HOCl/g fibrinogen (or ∼0–300 μM based on 2 mg/mL fibrinogen concentration) (22). Circular dichro...

Activated and Electrolyzed Water: A Brief Review of a New Generation of Cleaners and Sanitizing Agents

As a sanitizing agent, the main “ingredient” behind the germ-killing effect of modern activated water devices is electroporation. This is a scientific process that applies a low-level electrical fi...

Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13

We show in this study that neutrophil-derived oxidants are capable of readily oxidizing the methionine residue at the cleavage site for the VWF-processing enzyme ADAMTS13. 

Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity

The production of hypochlorous acid (HOCl) is a characteristic of granulocyte activation, a hallmark of the early phase of innate immune responses. In this study, we show that, in addition to its w...

Hypochlorous Acid as a Potential Wound Care Agent

HOCl is known to be the major strong oxidant produced by neutrophils, and is a potent microbicidal agent within these cells. Experimentally, it has been estimated that neutrophils stimulated in vit...